Laser Mass Spectrometry

Two Step Laser Mass Spectrometry

Laser Microprobe Mass Spectrometry LASER MICROPROBE MASS SPECTROMETRY: POSSIBILITIES AND LIMITATIONS

Laser microprobe mass spectrometry (LMMS) employs an intense UV pulse from a focused highpower laser to evaporate and ionize a microvolume (% 1 um3) of solid samples at relatively elevated energy density (106-101’ W cmm2). The ions produced by the interaction of photons with the condensed phase are then mass analyzed in a time-of-flight mass spectrometer and yield a complete mass spectrum on ea...

Isomeric identification by laser control mass spectrometry.

The influence shaped femtosecond laser pulses have on molecular photofragmentation and ionization, coupled with the intrinsic sensitivity of mass spectrometry, results in a powerful tool for fast, accurate, reproducible and quantitative isomeric identification. Complex phase functions are introduced to enhance differences during the laser-molecule interactions, which depend on geometric structu...

Laser Microprobe Mass Spectrometry: Possibilities and Limitations

Laser microprobe mass spectrometry (LMMS) offers a great potential for inorganic analysis and speciation as well as for organic structural characterization. This remarkable flexibility makes the results critically dependent on the experimental conditions, however, so an exact description is hard to achieve, since inaccessible local parameters are involved. The paper deals in detail with this as...

Laser Ablation Inductively Coupled Plasma Mass Spectrometry

New analytical techniques for multiparametric characterisation of individual cells are likely to reveal important information about the heterogeneity of immunological responses at the single-cell level. In this proof-of-principle study, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was applied to the problem of concurrently detecting 24 lineage and activation markers e...